Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population.

Wen-Ling Liao Yu-Nan HuangYa-Wen ChangTing-Yuan LiuHsing-Fang LuZih-Yu TiaoPen-Hua SuChung-Hsing WangFuu-Jen Tsai

Published in: Diabetes, obesity & metabolism (2023)

Polygenic risk score and HLA variations enable personalized risk estimates, enhance newborn screening efficiency for ketoacidosis prevention, and addresses the gap in data on T1D prediction in isolated Asian populations.

Keyphrases

type diabetes
risk assessment
endothelial cells
copy number
insulin resistance
metabolic syndrome
pluripotent stem cells
adipose tissue
big data
artificial intelligence
human health
skeletal muscle
induced pluripotent stem cells
genetic diversity
deep learning