Combination of Shengmai San and Radix puerariae ameliorates depression-like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression.

Ayaz AhmedGuirong ZengMudassar AzharFengzhong WangJingru WangBei FanXin-Min LiuDejiang JiangQiong Wang

Published in: Animal models and experimental medicine (2023)

This study showed that R-SMS formulation antagonized depressive symptoms in diabetic rats; thus, this formulation might be studied further to develop as an antidepressant.

Keyphrases

diabetic rats
depressive symptoms
oxidative stress
sleep quality
drug delivery
social support
mouse model
stress induced
physical activity