Heterogeneity of weight loss and transcriptomic signatures in pancreatic ductal adenocarcinoma.
Andrea N RinerKelly M HerremansVignesh VudathaSong HanXufeng QuJinze LiuNitai MukhopadhyayDevon C FreudenbergerThomas J GeorgeSarah M JudgeAndrew R JudgeSteven J HughesJose G TrevinoPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Resectable pancreatic head PDAC is associated with higher prevalence of significant weight loss and more poor prognosis features. Pancreaticobiliary obstruction and hypoalbuminemia in patients with head tumours suggests compounding effects of nutrient malabsorption and systemic inflammation on molecular drivers of cachexia, possibly contributing to shorter survival. Therefore, PDAC-associated cachexia is a heterogenous syndrome, which may be influenced by the primary tumour location. Select patients with resectable pancreatic head tumours may benefit from nutritional rehabilitation to improve outcomes.
Keyphrases
- poor prognosis
- weight loss
- optic nerve
- bariatric surgery
- long non coding rna
- single cell
- roux en y gastric bypass
- gastric bypass
- locally advanced
- risk factors
- liver metastases
- genome wide
- type diabetes
- case report
- metabolic syndrome
- rna seq
- dna methylation
- adipose tissue
- obese patients
- glycemic control
- rectal cancer
- single molecule