Evaluation of a novel non-invasive preimplantation genetic screening approach.

Valeriy KuznyetsovSvetlana MadjunkovaRan AntesRina AbramovGelareh MotamediZenon IbarrientosClifford Librach

Published in: PloS one (2018)

A combination of BCCM and BF contains sufficient embryonic DNA for whole genome amplification and accurate aneuploidy screening. Our findings suggest that aneuploidy screening using BCCM combined with BF could potentially serve as a novel NIPGS approach for use in human IVF.

Keyphrases

endothelial cells
nucleic acid
genome wide
high resolution
gene expression
circulating tumor
dna methylation
pregnant women
copy number
mass spectrometry
pregnancy outcomes
circulating tumor cells
pluripotent stem cells