Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales.
Kiran SamraAmy M MacDougallGeorgia PeakmanArabella BouziguesMartina BocchettaDavid M CashCaroline V GreavesRhian S ConveryJohn C van SwietenLize JiskootHarro SeelaarFermin MorenoRaquel Sanchez-ValleRobert LaforceCaroline GraffMario MasellisCarmela TartagliaJames B RoweBarbara BorroniElizabeth FingerMatthis SynofzikDaniela GalimbertiRik VandenbergheAlexandre de MendonçaChris R ButlerAlexander GerhardSimon DucharmeIsabelle Le BerPietro TiraboschiIsabel SantanaFlorence PasquierJohannes LevinMarkus OttoSandro SorbiJonathan D RohrerLucy L Russellnull nullPublished in: Journal of neurology (2022)
Motor features are present in mutation carriers at all disease stages across all three genetic groups. Inclusion of motor symptoms in a rating scale that can be used in future clinical trials will not only ensure a more accurate severity measure is recorded but that a wider spectrum of FTD phenotypes can be included in the same trial.