Exploring the Spectrum of Long Non-Coding RNA CARMN in Physiological and Pathological Contexts.
Hui LiChuannan SunBin LuoChuzhi ZhanWeitao LiLu DengKang KangDeming GouPublished in: Biomolecules (2024)
Cardiac mesoderm enhancer-associated non-coding RNA (CARMN), an evolutionarily conserved long non-coding RNA (lncRNA), serves as the host gene for the miR143/145 cluster. It plays a crucial role in cardiovascular cell differentiation and the maintenance of vascular smooth muscle cell (VSMC) homeostasis, which are vital for normal physiological processes. Specifically, CARMN is associated with the pathological progression of cardiovascular diseases such as atherosclerosis, abdominal aortic aneurysm, and chronic heart failure. Moreover, it acts as a tumor suppressor in various cancers, including hepatocellular carcinoma, bladder cancer, and breast cancer, highlighting its potential as a beneficial biomarker and therapeutic target. This review provides a detailed examination of the roles of CARMN, its evolutionary conservation, expression patterns, and regulatory mechanisms. It also outlines its significant implications in the diagnosis, prognosis, and treatment of these diseases, underscoring the need for further translational research to exploit its clinical potential.
Keyphrases
- long non coding rna
- poor prognosis
- smooth muscle
- abdominal aortic aneurysm
- cardiovascular disease
- transcription factor
- genome wide
- binding protein
- single cell
- cell therapy
- copy number
- genome wide identification
- stem cells
- human health
- risk assessment
- cell proliferation
- cardiovascular risk factors
- climate change
- coronary artery disease
- combination therapy
- gene expression
- mesenchymal stem cells
- metabolic syndrome
- long noncoding rna
- cardiovascular events
- nucleic acid
- muscle invasive bladder cancer