Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation.
Ayumi MitsuneMitsuhiro YamadaNaoya FujinoTadahisa NumakuraTomohiro IchikawaAyumi SuzukiShuichiro MatsumotoYoshiya MitsuhashiKoji ItakuraTomonori MakiguchiAkira KoaraiTsutomu TamadaShota EndoToshiyuki TakaiYoshinori OkadaSatoshi SuzukiMasakazu IchinoseHisatoshi SugiuraPublished in: Respiratory research (2021)
LILRB4 on interstitial macrophages was upregulated both in human COPD lungs and in a mouse model of emphysema. This upregulated LILRB4 may have a protective effect against emphysema formation, possibly through decreasing MMP-12 expression in the lungs.