TAFRO syndrome complicated by porto-sinusoidal vascular liver disease with portal hypertension: a case report.
Manabu HayashiJun WadaMasashi FujitaTomoyuki AsanoNaoki MatsuokaYuya FujitaJumpei TemmokuHaruki MatsumotoMakiko Yashio-FuruyaShuzo SatoHiroko KobayashiHiroshi WatanabeKobashi RyoichiroYuichi WaragaiErina SuzukiYuichiro KikoKazumichi AbeAtsushi TakahashiTomoyuki MasudaYuko HashimotoKiyoshi MigitaHiromasa OhiraPublished in: Clinical journal of gastroenterology (2021)
Porto-sinusoidal vascular liver disease (PSVD) is a disorder that can cause portal hypertension without liver cirrhosis. TAFRO syndrome is a systemic inflammatory disorder with a background of immunological abnormalities. We report a case of TAFRO syndrome complicated by PSVD with portal hypertension. A 39-year-old man developed refractory ascites and esophageal varices. Lymph node histology revealed multicentric Castleman disease-like features. Intravenous methylprednisolone and tocilizumab therapy improved ascites and renal dysfunction, but the patient developed severe infections. The diagnosis of TAFRO syndrome in patients complicated by PSVD with portal hypertension encourages the consideration of appropriate treatment for these patients.
Keyphrases
- blood pressure
- end stage renal disease
- lymph node
- case report
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- oxidative stress
- squamous cell carcinoma
- rheumatoid arthritis
- stem cells
- radiation therapy
- neoadjuvant chemotherapy
- systemic lupus erythematosus
- bone marrow
- patient reported outcomes
- patient reported
- mesenchymal stem cells
- rheumatoid arthritis patients