Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease.
Gopika SenthilKumarBoran KatunaricZachary ZirgibelBrian J LindemerMaria J Jaramillo-TorresHenry Bordas-MurphyMary E SchulzPaul J PearsonJulie K FreedPublished in: Circulation research (2023)
These data suggest that despite differential downstream signaling between health and disease, NSmase-mediated ceramide formation is necessary for proper functioning of the human microvascular endothelium. Therapeutic strategies that aim to significantly lower ceramide formation may prove detrimental to the microvasculature.