Sonic vibration (SV), or vibroacoustic therapy, is applied to enhance local and systemic blood circulation and alleviate pain using low-frequency sine wave vibrations. However, there is limited scientific data on the mechanisms through which the benefits are achieved. In this study, we investigated the impact of SV on inflammatory responses by assessing cytokine secretion in both in vivo and in vitro models. After inducing inflammatory responses in mice and macrophages, we studied cytokine expression and the symptoms of inflammatory diseases in response to three frequencies (14, 45, or 90 Hz) of SV stimulation at 0.5 m/s 2 of amplitude. The results showed that SV at 90 Hz significantly increased interelukin-10 (IL-10) secretion in mice who were administered lipopolysaccharides (LPS) and increased the expression of IL-10 transcripts in peritoneal exudate cells and macrophages. Furthermore, SV at 90 Hz improved LPS-induced lethality and alleviated symptoms in a colitis model. In conclusion, this study scientifically proves the anti-inflammatory effects of vibration therapy through its ability to increase IL-10 expression.
Keyphrases
- poor prognosis
- lps induced
- inflammatory response
- anti inflammatory
- high frequency
- oxidative stress
- induced apoptosis
- type diabetes
- physical activity
- machine learning
- pain management
- mesenchymal stem cells
- stem cells
- big data
- bone marrow
- adipose tissue
- mouse model
- cell cycle arrest
- cell death
- spinal cord
- neuropathic pain
- endoplasmic reticulum stress
- atomic force microscopy
- high resolution
- mass spectrometry
- cell therapy
- pi k akt
- ulcerative colitis