Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.

Zahra Khosravi BabadiEnge SudarmanGholam Hossein EbrahimipourGian PrimahanaMarc StadlerJoachim Wink

Published in: The Journal of antibiotics (2019)

The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC50 value of 5.4 µM.

Keyphrases

cell cycle arrest
induced apoptosis
high resolution
endothelial cells
magnetic resonance
ms ms
electronic health record
induced pluripotent stem cells
high intensity
big data
pluripotent stem cells
preterm birth
oxidative stress
solid state
signaling pathway
cell proliferation
machine learning