Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.

Qi ZhangBingqiu XiuLiyi ZhangMing ChenWeiru ChiLun LiRong GuoJingyan XueBenlong YangXiaoyan HuangZhi-Ming ShaoShenglin HuangYayun ChiJiong Wu

Published in: Journal for immunotherapy of cancer (2022)

In summary, these results suggest that LINC00624 is a cancer immunosuppressive lncRNA and targeting LINC00624 through ASOs in tumors expressing high levels of LINC00624 has great therapeutic potential in future clinical applications.

Keyphrases

long non coding rna
long noncoding rna
poor prognosis
cell proliferation
papillary thyroid
cancer therapy
squamous cell carcinoma
stem cells
lymph node metastasis