Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.

Robyn M Busch Lamis YehiaPeter BazeleyMarilyn Seyfi Ingmar Bluemcke Bruce P Hermann Imad M Najm Charis Eng

Published in: Epilepsia (2020)

TLE-associated memory status may be influenced by differences in gene expression profiles within the temporal lobe. Upstream processes influencing differential expression signatures, such as miRNAs, could serve as biomarkers and potential treatment targets for memory impairment in TLE.

Keyphrases

working memory
genome wide
temporal lobe epilepsy
gene expression
copy number
oxidative stress
dna methylation
single cell
resting state
rna seq
human health
transcription factor
risk assessment
climate change
combination therapy
multiple sclerosis