RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy.
Cui WangShibo YaoTinghui ZhangXiaoya SunChenjun BaiPing-Kun ZhouPublished in: International journal of molecular sciences (2024)
The N6-methyladenosine (M6A) modification is the most common internal chemical modification of RNA molecules in eukaryotes. This modification can affect mRNA metabolism, regulate RNA transcription, nuclear export, splicing, degradation, and translation, and significantly impact various aspects of physiology and pathobiology. Radiotherapy is the most common method of tumor treatment. Different intrinsic cellular mechanisms affect the response of cells to ionizing radiation (IR) and the effectiveness of cancer radiotherapy. In this review, we summarize and discuss recent advances in understanding the roles and mechanisms of RNA M6A methylation in cellular responses to radiation-induced DNA damage and in determining the outcomes of cancer radiotherapy. Insights into RNA M6A methylation in radiation biology may facilitate the improvement of therapeutic strategies for cancer radiotherapy and radioprotection of normal tissues.
Keyphrases
- radiation induced
- papillary thyroid
- early stage
- radiation therapy
- squamous cell
- dna damage
- locally advanced
- dna damage response
- systematic review
- randomized controlled trial
- gene expression
- oxidative stress
- squamous cell carcinoma
- metabolic syndrome
- nucleic acid
- genome wide
- adipose tissue
- cell death
- cell proliferation
- cell cycle arrest
- binding protein
- insulin resistance