Long non-coding RNA XLOC_000647 suppresses progression of pancreatic cancer and decreases epithelial-mesenchymal transition-induced cell invasion by down-regulating NLRP3.

Hao HuYandong WangXiangya DingYuan HeZipeng LuPengfei WuLei TianHao YuanDongfang LiuGuodong ShiTianfang XiaJie YinBaobao CaiYi MiaoKui-Rong Jiang

Published in: Molecular cancer (2018)

Together, these results indicate that XLOC_000647 functions as a novel tumor suppressor of lncRNA and acts as an important regulator of NLRP3, inhibiting cell proliferation, invasion, and EMT in PC.

Keyphrases

long non coding rna
epithelial mesenchymal transition
signaling pathway
cell proliferation
poor prognosis
pi k akt
transforming growth factor
high glucose
diabetic rats
nlrp inflammasome
cell cycle
cell migration
drug induced
oxidative stress
long noncoding rna