Prediction of Biomarker Expression on Primary Pancreatic Ductal Adenocarcinoma Tissues Using Fine-Needle Biopsies: Paving the Way for a Patient-Tailored Molecular Imaging Approach.

Ruben D HouvastMaurice van DuijvenvoordeJiaXin ChuaMireille VankemmelbekeLindy G DurrantAkin IndersonJeanin E van HooftJ Sven D MieogBert A BonsingCornelis F M SierA Stijn L P CrobachAlexander L VahrmeijerPeter J K Kuppen

Published in: Molecular diagnosis & therapy (2023)

This study demonstrated that biomarker expression in FNB tissues is predictive for PT expression, irrespective of the application of NAT. These findings thereby provide the foundation for the clinical application of an FNB-based biomarker-screening workflow, eventually facilitating a patient-specific approach of molecular imaging tracer administration in PDAC.

Keyphrases

poor prognosis
gene expression
binding protein
ultrasound guided
air pollution