Potential biomarkers and therapeutic targets of idiopathic pulmonary arterial hypertension.

Wenjun HeXi SuLingdan ChenChunli LiuWenju LuTao WangJian Wang

Published in: Physiological reports (2022)

Our findings collectively suggest that the expression levels of PDK4, RBPMS2, and PDE5A in PBMCs are associated with the expression of these genes in lung tissues. Thus, these molecules may serve as potential circulating biomarkers and/or possible therapeutic targets for IPAH.

Keyphrases

pulmonary arterial hypertension
poor prognosis
pulmonary artery
pulmonary hypertension
gene expression
genome wide
long non coding rna
dna methylation
risk assessment
climate change
genome wide analysis