Direct Cross-Coupling of Allylic C(sp3 )-H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis.
Long HuangMagnus RuepingPublished in: Angewandte Chemie (International ed. in English) (2018)
An efficient protocol for the direct allylic C(sp3 )-H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp2 )-C(sp3 ) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.