Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort.

Uruj HodaStelios PavlidisAruna T BansalKentaro TakahashiSile HuFrancois Ng Kee KwongChristos RossiosKai SunPankaj BhavsarMatthew LozaFrederic BaribaudPascal ChanezStephen J FowlerIldiko HorvathPaolo MontuschiFlorian SingerJacek MusialBarbro DahlenNorbert KrugThomas SandstromDominic E ShawRene LutterLouise J FlemingPeter H HowarthMassimo CarusoAna R SousaJulie CorfieldCharles AuffrayBertrand De MeulderDiane LefaudeuxSven-Erik DahlenRatko DjukanovicPeter J SterkYike GuoIan M AdcockKian Fan Chungnull null

Published in: Clinical and translational medicine (2022)

The FE group and its PFE subgroup are associated with poor asthma control while expressing higher type 1 and type 2 activation pathways compared to IE and PIE, respectively.

Keyphrases

chronic obstructive pulmonary disease
lung function
single cell
rna seq
randomized controlled trial
clinical trial
air pollution
study protocol
open label