Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Lijo Cherian OzhathilClémence DelalandeBeatrice BianchiGabor NemethSven KappelUrs ThometDaniela Ross-KaschitzaCéline SimoninMatthias RubinJürg GertschMartin LochnerChristine PeineltJean-Louis ReymondHugues Abriel

Published in: British journal of pharmacology (2018)

The discovery of compound 5, a potent and selective inhibitor of TRPM4 with an additional chemical chaperone feature, revealed new opportunities for studying the role of TRPM4 in human diseases and developing clinical drug candidates.

Keyphrases

small molecule
endothelial cells
protein protein
anti inflammatory
machine learning
induced pluripotent stem cells
single cell
deep learning
heat shock protein
emergency department
pluripotent stem cells
heat shock
oxidative stress
adverse drug