Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia.

Rafael Rivas-SantistebanAna I Rodriguez-PerezAna MuñozIrene Reyes-ResinaJosé Luis Labandeira-GarcíaGemma NavarroRafael Franco

Published in: Journal of neuroinflammation (2020)

The results indicate that boosting the action of neuroprotective AT2 receptors using an AT1 receptor antagonist constitutes a promising therapeutic strategy in PD.

Keyphrases

poor prognosis
high glucose
diabetic rats
binding protein
parkinson disease
angiotensin ii
deep brain stimulation
angiotensin converting enzyme
cerebral ischemia