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[ 68  Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity.

Zachary T RosenkransChristopher F MasseyKsenija BernauCarolina A FerreiraJustin J JefferyJefree J SchulteMelissa MooreFrank VallaJeanine M BattertonChristopher R DrakeAlan B McMillanNathan SandboAli PirastehReinier Hernandez
Published in: European journal of nuclear medicine and molecular imaging (2022)
CT was unable to assess disease activity in a murine model of IPF. Conversely, FAPI PET detected both the presence and activity of lung fibrogenesis, making it a promising tool for assessing early disease activity and evaluating the efficacy of therapeutic interventions in lung fibrosis patients.
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