[ 68 Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity.
Zachary T RosenkransChristopher F MasseyKsenija BernauCarolina A FerreiraJustin J JefferyJefree J SchulteMelissa MooreFrank VallaJeanine M BattertonChristopher R DrakeAlan B McMillanNathan SandboAli PirastehReinier HernandezPublished in: European journal of nuclear medicine and molecular imaging (2022)
CT was unable to assess disease activity in a murine model of IPF. Conversely, FAPI PET detected both the presence and activity of lung fibrogenesis, making it a promising tool for assessing early disease activity and evaluating the efficacy of therapeutic interventions in lung fibrosis patients.
Keyphrases
- disease activity
- pet ct
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- computed tomography
- positron emission tomography
- juvenile idiopathic arthritis
- pulmonary fibrosis
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- physical activity
- peritoneal dialysis
- pet imaging
- magnetic resonance imaging
- contrast enhanced
- magnetic resonance
- image quality
- label free
- sensitive detection