Overexpression of metastasis-associated in colon cancer 1 in retinoblastoma.

Rohini M NairVarsha PrabhuRadhika ManukondaDilip K MishraSwathi KalikiGeeta K Vemuganti

Published in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2020)

Overexpression of MACC1 and c-MET in retinoblastoma tissues, specifically those with risk factors for metastasis, suggests its role in proliferation and possibly in invasion. However, the current data do not support it to be a clinical prognostic marker in retinoblastoma tumours. The inverse serum expression is an intriguing finding, which warrants further studies especially in retinoblastoma.

Keyphrases

cell proliferation
poor prognosis
transcription factor
signaling pathway
gene expression
big data
tyrosine kinase
machine learning
long non coding rna
artificial intelligence
case control