Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations.

Junghyun Jo Lin Yang Hoang-Dai TranWeonjin YuAlfred Xuyang SunYa Yin ChangByung Chul JungSeung-Jae LeeTzuen Yih SawBin XiaoAudrey Tze Ting KhooLai-Ping Yaw Jessica Jiaxin XieHidayat LokmanWei-Yi OngGrace Gui Yin LimKah-Leong LimEng-King TanHuck-Hui NgHyunsoo Shawn Je

Published in: Annals of neurology (2021)

Taken together, the data indicate that our hMLOs harboring 2 major risk factors (glucocerebrosidase deficiency and wild-type α-syn overproduction) of Parkinson disease provide a tractable model to further elucidate the underlying mechanisms for progressive Lewy body formation. ANN NEUROL 2021;90:490-505.

Keyphrases

parkinson disease
wild type
deep brain stimulation
risk factors
induced pluripotent stem cells
endothelial cells
multiple sclerosis
electronic health record
pluripotent stem cells
big data
neural network
machine learning
smoking cessation