ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.

Junpeng MengHongkun CaiYan SunShuang WenHeshui WuDianyun Ren

Published in: Cellular oncology (Dordrecht) (2022)

Our data indicate that ITGA2 induces STING expression by interacting with DNMT1 and inducing the degradation of DNMT1. ITGA2 silencing combined with DNMT1 inhibitor treatment may be a novel therapeutic strategy for pancreatic cancer.

Keyphrases

dna methylation
poor prognosis
gene expression
binding protein
long non coding rna
big data
machine learning