Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma.
Santiago A Lozano CalderónJose Ignacio AlbergoOlivier Q GrootNelson A MerchanJad M El AbiadVanessa SalinasLuis Carlos Gomez MierCamilo Soto MontoyaMarco L FerroneJohn E ReadyFrancisco J LinaresAdam S LevinManuel Peleteiro PensadoJosé Juan Pozo KreilingerIrene Barrientos RuizEduardo J Ortiz-CruzMark C GebhardtGregory M CoteEdwin ChoyDimitrios SpentzosYin Pun HungVikram DeshpandeIvan A ChebibRobert Allan McCullochGermán FarfalliLuis Aponte TinaoCarol D MorrisGunnlaugur Petur NielsenMegan E AndersonLee M JeysPublished in: Cancer (2022)
Complete tumor necrosis should be the index parameter to grade response to treatment as satisfactory in patients with Ewing sarcoma. Any viable tumor in these patients after neoadjuvant treatment should be of oncologic concern. These findings can affect the design of new clinical trials and the risk-stratified application of conventional or novel treatments.