Cyclooxygenase-2 expression in colorectal carcinoma, adenomatous polyps and non-tumour bearing margins of resection tissues in a cohort of black Africans.

Uchenna Simon EzenkwaClement Abu OkoloGabriel Olabiyi OgunAdegboyega AkereOlufemi John Ogunbiyi

Published in: PloS one (2021)

This study showed a progressive increase in COX-2 expression from normal to adenomatous polyp and CRC tissues, this being associated with poorer prognostic indicators. Although COX-2 appears early in CRC, it may play a secondary role in promoting tumour growth and invasiveness.

Keyphrases

poor prognosis
gene expression
multiple sclerosis
binding protein
long non coding rna