Login / Signup

Induction of p16Ink4a Gene Expression in Heme Protein-Induced Acute Kidney Injury and by Heme: Pathophysiologic Implications.

Karl A NathRaman Deep SinghAnthony J CroattAllan W AckermanJoseph P GrandeDaniel R O'BrienVesna D GarovicChristopher M AdamsTamara TchkoniaJames L Kirkland
Published in: Kidney360 (2024)
The pathogenesis of HP-AKI involves senescence and the induction of p16Ink4a, the latter driven, in part, by hemoglobin, myoglobin, and heme.
Keyphrases
  • acute kidney injury
  • gene expression
  • cardiac surgery
  • high glucose
  • dna methylation
  • endothelial cells
  • dna damage
  • diabetic rats
  • stress induced
  • binding protein
  • amino acid
  • oxidative stress
  • small molecule