Induction of p16Ink4a Gene Expression in Heme Protein-Induced Acute Kidney Injury and by Heme: Pathophysiologic Implications.
Karl A NathRaman Deep SinghAnthony J CroattAllan W AckermanJoseph P GrandeDaniel R O'BrienVesna D GarovicChristopher M AdamsTamara TchkoniaJames L KirklandPublished in: Kidney360 (2024)
The pathogenesis of HP-AKI involves senescence and the induction of p16Ink4a, the latter driven, in part, by hemoglobin, myoglobin, and heme.