James L Kirkland (James Kirkland)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 61

Top Topics

Monoclonal Antibody

Top Venues

Research square

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Nadia Akhiyat, Ilke Özcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley R Lewis, Lilach Orly Lerman, Amir Lerman
Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho. Journal of the American Heart Association 13 (9) (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Joshua N Farr, Elizabeth J Atkinson, Sara J Achenbach, Tammie L Volkman, Amanda J Tweed, Stephanie J Vos, Ming Ruan, Jad G Sfeir, Matthew T Drake, Dominik Saul, Madison L Doolittle, Irina Bancos, Kai Yu, Tamara Tchkonia, Nathan K LeBrasseur, James L Kirkland, David G Monroe, Sundeep Khosla
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nature medicine (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Nadia Akhiyat, Ilke Özcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley R Lewis, Lilach Orly Lerman, Amir Lerman
Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho. Journal of the American Heart Association 13 (9) (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced Acute Kidney Injury and by Heme: Pathophysiologic Implications. Kidney360 (2024)
Nadia Akhiyat, Ilke Özcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley R Lewis, Lilach Orly Lerman, Amir Lerman
Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho. Journal of the American Heart Association 13 (9) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan I Macura, Tamara Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology 7 (1) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan I Macura, Tamara Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology 7 (1) (2024)
Miranda E Orr, Valentina Garbarino, Juan Pablo Palavicini, Justin Melendez, Nicolas R Barthélemy, Yingxin He, Tiffany Kautz, Marisa Lopez-Cruzan, Julia Mathews, Peng Xu, Bin Zhang, Afaf Saliba, Nagarjunachary Ragi, Kumar Sharma, Suzanne Craft, Ronald C Petersen, Jair Espindola-Netto, Ailing Xue, Tamara Tchkonia, James L Kirkland, Sudha Seshadri, Arash Salardini, Nicolas Musi, Randell J Bateman, Mitzi Gonzales
Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease. Research square (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Daniel R O'Brien, Vesna D Garovic, Christopher M Adams, Tamara Tchkonia, James L Kirkland
Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360 5 (4) (2024)
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray Guseh, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert R Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss J Chang, Amy A Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, null null, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science translational medicine 16 (743) (2024)
Miranda E Orr, Valentina Garbarino, Juan Pablo Palavicini, Justin Melendez, Nicolas R Barthélemy, Yingxin He, Tiffany Kautz, Marisa Lopez-Cruzan, Julia Mathews, Peng Xu, Bin Zhang, Afaf Saliba, Nagarjunachary Ragi, Kumar Sharma, Suzanne Craft, Ronald C Petersen, Jair Espindola-Netto, Ailing Xue, Tamara Tchkonia, James L Kirkland, Sudha Seshadri, Arash Salardini, Nicolas Musi, Randell J Bateman, Mitzi Gonzales
Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease. Research square (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Nadia Akhiyat, Ilke Özcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley R Lewis, Lilach Orly Lerman, Amir Lerman
Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho. Journal of the American Heart Association (2024)
Nadia Akhiyat, Ilke Özcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley R Lewis, Lilach Orly Lerman, Amir Lerman
Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho. Journal of the American Heart Association 13 (9) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Masayoshi Suda, Karl H Paul, Utkarsh Tripathi, Tohru Minamino, Tamara Tchkonia, James L Kirkland
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction. Endocrine reviews (2024)
Valentina R Garbarino, Juan Pablo Palavicini, Justin Melendez, Nicolas R Barthélemy, Yingxin He, Tiffany F Kautz, Marisa Lopez-Cruzan, Julia J Mathews, Peng Xu, Bin Zhan, Afaf Saliba, Nagarjunachary Ragi, Kumar Sharma, Suzanne Craft, Ronald C Petersen, Jair Machado Espindola-Netto, Ailing Xue, Tamara Tchkonia, James L Kirkland, Sudha Seshadri, Arash Salardini, Nicolas Musi, Randell J Bateman, Mitzi M Gonzales, Miranda E Orr
Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease. Research square (2024)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K LeBrasseur, James L Kirkland, Eduardo Nunes Chini, Qing Wei, Kun Ling, Jinghua Hu
A stress-induced cilium-to-PML-NB route drives senescence initiation. Nature communications 14 (1) (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Larissa G P Langhi Prata, Tamar Tchkonia, James L Kirkland
Cell senescence, the senescence-associated secretory phenotype, and cancers. PLoS biology 21 (9) (2023)
Cecile Riviere-Cazaux, Lucas P Carlstrom, Bryan J Neth, Ian E Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A Mansour, Bipasha Mukherjee, Arthur E Warrington, Susan C Short, Thomas von Zglinicki, Desmond A Brown, Sandeep Burma, Tamara Tchkonia, Marissa J Schafer, Darren J Baker, Sani H Kizilbash, James L Kirkland, Terry C Burns
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence. NPJ precision oncology 7 (1) (2023)
Yves Rolland, Felipe Sierra, Luigi Ferruci, Nir Barzilai, Rafael De Cabo, Joan Mannick, Anthony Oliva, William Evans, Davide Angioni, Philipe De Souto Barreto, Jeremy Raffin, Bruno Vellas, James L Kirkland, null null
Challenges in developing Geroscience trials. Nature communications 14 (1) (2023)
Mitzi M Gonzales, Valentina R Garbarino, Tiffany F Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia J Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E Orr
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial. Nature medicine (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Clemens A Schmitt, Tamar Tchkonia, Laura J Niedernhofer, Paul D Robbins, James L Kirkland, Soyoung Lee
COVID-19 and cellular senescence. Nature reviews. Immunology (2022)
Pataje G S Prasanna, Deborah E Citrin, Jeffrey Hildesheim, Mansoor M Ahmed, Sundar Venkatachalam, Gabriela Riscuta, Dan Xi, Guangrong Zheng, Jan van Deursen, Jorg J Goronzy, Stephen J Kron, Mitchell S Anscher, Norman E Sharpless, Pierre-Yves Desprez, Stephen L Brown, Laura J Niedernhofer, Ana O'Loghlen, Alexandros G Georgakilas, François Paris, David Gius, David A Gewirtz, Clemens A Schmitt, Mohamed E Abazeed, James L Kirkland, Ann Richmond, Paul B Romesser, Scott W Lowe, Jesús Gil, Marc S Mendonca, Sandeep Burma, Daohong Zhou, C Norman Coleman
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. Journal of the National Cancer Institute 113 (10) (2022)
Xu Zhang, Vesselina M Pearsall, Chase M Carver, Elizabeth J Atkinson, Benjamin D S Clarkson, Ethan M Grund, Michelle Baez-Faria, Kevin D Pavelko, Jennifer M Kachergus, Thomas A White, Renee K Johnson, Courtney S Malo, Alan M Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O Johnson, Zachariah P Tritz, Cori E Fain, Roman H Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L Kirkland, Aaron J Johnson, Charles L Howe, E Aubrey Thompson, Nathan K LeBrasseur, Marissa J Schafer
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance. Nature communications 13 (1) (2022)
Masum Rahman, Ian Olson, Moustafa Mansour, Lucas P Carlstrom, Rujapope Sutiwisesak, Rehan Saber, Karishma Rajani, Arthur E Warrington, Adam Howard, Mark Schroeder, Sisi Chen, Paul A Decker, Eliot F Sananikone, Yi Zhu, Tamar Tchkonia, Ian F Parney, Sandeep Burma, Desmond A Brown, Moses Rodriguez, Jann N Sarkaria, James L Kirkland, Terry C Burns
Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition. Molecular cancer research : MCR 20 (6) (2022)
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J Atkinson, Madison L Doolittle, Xu Zhang, Nathan K LeBrasseur, Robert J Pignolo, Paul D Robbins, Laura J Niedernhofer, Yuji Ikeno, Diana Jurk, João F Passos, LaTonya J Hickson, Ailing Xue, David G Monroe, Tamara Tchkonia, James L Kirkland, Joshua N Farr, Sundeep Khosla
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nature communications 13 (1) (2022)
Selim Chaib, Tamara Tchkonia, James L Kirkland
Cellular senescence and senolytics: the path to the clinic. Nature medicine 28 (8) (2022)
Ritesh K Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamara Tchkonia, James L Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Blüher, Ulf Smith
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH. Nature metabolism 4 (8) (2022)
Wei Jun Huang, LaTonya J Hickson, Alfonso Eirin, James L Kirkland, Lilach Orly Lerman
Cellular senescence: the good, the bad and the unknown. Nature reviews. Nephrology 18 (10) (2022)
Qixia Xu, Qiang Fu, Zi Li, Hanxin Liu, Ying Wang, Xu Lin, Ruikun He, Xuguang Zhang, Zhenyu Ju, Judith Campisi, James L Kirkland, Yu Sun
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nature metabolism (2021)
Allyson K Palmer, Tamar Tchkonia, James L Kirkland
Senolytics: Potential for Alleviating Diabetes and Its Complications. Endocrinology 162 (8) (2021)
Christina D Camell, Matthew J Yousefzadeh, Yi Zhu, Larissa G P Langhi Prata, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Peng Cheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christina L Inman, Kurt O Johnson, Stephanie H Cholensky, Timothy W Carlson, Nathan K LeBrasseur, Sundeep Khosla, M Gerard O'Sullivan, David B Allison, Stephen C Jameson, Alexander Meves, Ming Li, Y S Prakash, Sergio E Chiarella, Sara E Hamilton, Tamara Tchkonia, Laura J Niedernhofer, James L Kirkland, Paul D Robbins
Senolytics reduce coronavirus-related mortality in old mice. Science (New York, N.Y.) 373 (6552) (2021)
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