Clinical utility of [68Ga]Ga-PSMA-11 PET/CT in initial staging of patients with prostate cancer and importance of intraprostatic SUVmax values.
Ivan RogicAnja Tea GolubicMarijan ZuvicTea SmitranNino JukicMarija GamulinZeljko KastelanDrazen HuicPublished in: Nuclear medicine review. Central & Eastern Europe (2024)
In our study, [68Ga]Ga-PSMA-11 PET/CT scans detected the extended disease in more than half of the patients. Locating disease beyond the prostate gland allowed better informed clinical decisions and modified treatment. A positive correlation was found between intraprostatic SUVmax values and the ISUP group of prostate cancer. High-risk patients had SUVmax values that were significantly higher than those of low-risk patients. The correlation between the Gleason score and SUVmax value can be explained by the increased intensity of PSMA expression as the tumor grade increases.
Keyphrases
- pet ct
- prostate cancer
- end stage renal disease
- positron emission tomography
- ejection fraction
- newly diagnosed
- chronic kidney disease
- radical prostatectomy
- prognostic factors
- peritoneal dialysis
- poor prognosis
- computed tomography
- lymph node
- magnetic resonance
- patient reported outcomes
- binding protein
- smoking cessation