Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.

Sharona Tornovsky-BabeayNoa Weinberg-CoremRachel Ben-Haroush Schyr Dana AvrahamiJudith LaviEseye FelekeKlaus H Kaestner Yuval Dor Benjamin Glaser

Published in: Diabetologia (2021)

We propose that increased workload-driven biphasic beta cell dynamics contribute to decreased beta cell function observed in long-standing congenital hyperinsulinism and type 2 diabetes.

Keyphrases

type diabetes
mouse model
single cell
cell therapy
cardiovascular disease
glycemic control
insulin resistance
stem cells