Klaus H Kaestner (Klaus Kaestner)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Venues

Cancer research

Nature communications

Diabetes

medRxiv : the preprint server for health sciences

University of Pennsylvania

Johns Hopkins School of Medicine (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania Jan 01 1997

United States

Professor :: Genetics

Education History

Johns Hopkins School of Medicine Sep 01 1986 - May 15 1990

United States

PHD :: Biochemistry, Cellular and Molecular Biology

Publications

Guoli Zhu, Deeksha Lahori, Jonathan Schug, Klaus H Kaestner
Villification of the intestinal epithelium is driven by Foxl1. bioRxiv : the preprint server for biology (2024)
Aanchal Mongia, Fatema Tuz Zohora, Noah G Burget, Yeqiao Zhou, Diane C Saunders, Yue J Wang, Marcela Brissova, Alvin C Powers, Klaus H Kaestner, Golnaz Vahedi, Ali Naji, Gregory W Schwartz, Robert B Faryabi
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. Nature communications 15 (1) (2024)
Guoli Zhu, Deeksha Lahori, Jonathan Schug, Klaus H Kaestner
Villification of the intestinal epithelium is driven by Foxl1. bioRxiv : the preprint server for biology (2024)
Klaus H Kaestner, Guoli Zhu, Deeksha Lahori, Jonathan Schug
Villification of the intestinal epithelium is driven by Foxl1. Research square (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research (2024)
Bao Khanh Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Nikhil N Kulkarni, Matthew C Pahl, James A Pippin, Chun Su, Klaus H Kaestner, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason W Hoskins, Laufey T Amundadottir, Mai Xu, Kevin K Brown, Stewart A Anderson, Wenli Yang, Paul M Titchenell, Patrick Seale, Babette S Zemel, Alessandra Chesi, Neil Romberg, Megan K Levings, Struan F A Grant, Andrew D Wells
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility. medRxiv : the preprint server for health sciences (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research 84 (14) (2024)
Aanchal Mongia, Fatema Tuz Zohora, Noah G Burget, Yeqiao Zhou, Diane C Saunders, Yue J Wang, Marcela Brissova, Alvin C Powers, Klaus H Kaestner, Golnaz Vahedi, Ali Naji, Gregory W Schwartz, Robert B Faryabi
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. Nature communications 15 (1) (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research 84 (14) (2024)
Riham Smoom, Catherine Lee May, Emmanuel Skordalakes, Klaus H Kaestner, Yehuda Tzfati
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1. bioRxiv : the preprint server for biology (2024)
Bao Khanh Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Nikhil N Kulkarni, Matthew C Pahl, James A Pippin, Chun Su, Klaus H Kaestner, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason W Hoskins, Laufey T Amundadottir, Mai Xu, Kevin K Brown, Stewart A Anderson, Wenli Yang, Paul M Titchenell, Patrick Seale, Babette S Zemel, Alessandra Chesi, Neil Romberg, Megan K Levings, Struan F A Grant, Andrew D Wells
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility. medRxiv : the preprint server for health sciences (2024)
Aanchal Mongia, Fatema Tuz Zohora, Noah G Burget, Yeqiao Zhou, Diane C Saunders, Yue J Wang, Marcela Brissova, Alvin C Powers, Klaus H Kaestner, Golnaz Vahedi, Ali Naji, Gregory W Schwartz, Robert B Faryabi
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. Nature communications 15 (1) (2024)
Bao Khanh Trang, Alessandra Chesi, Sylvanus Toikumo, James A Pippin, Matthew C Pahl, Joan M O'Brien, Laufey T Amundadottir, Kevin K Brown, Wenli Yang, Jaclyn E Welles, Dominic Santoleri, Paul M Titchenell, Patrick Seale, Babette S Zemel, Yadav Wagley, Kurt D Hankenson, Klaus H Kaestner, Stewart A Anderson, Matthew S Kayser, Andrew D Wells, Henry R Kranzler, Rachel L Kember, Struan F A Grant
Shared and unique 3D genomic features of substance use disorders across multiple cell types. medRxiv : the preprint server for health sciences (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research 84 (14) (2024)
Amin Abedini, Jonathan Levinsohn, Konstantin A Klötzer, Bernhard Dumoulin, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Andi M Bergeson, Kishor Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, Steven S Pullen, Carine M Boustany-Kari, Paolo Guarnieri, Anil Karihaloo, Daniel Traum, Hanying Yan, Kyle Coleman, Matthew Palmer, Lea Sarov-Blat, Lori Morton, Christopher A Hunter, Klaus H Kaestner, Mingyao Li, Katalin Suszták
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression. Nature genetics 56 (8) (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research 84 (14) (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research (2024)
Jonathan H Sussman, Nathalia Y Kim, Samantha B Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L Beatty, Klaus H Kaestner, Amber L Simpson, Ben Z Stanger
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Cancer research (2024)
Amin Abedini, Jonathan Levinsohn, Konstantin A Klötzer, Bernhard Dumoulin, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Andi M Bergeson, Kishor Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, Steven S Pullen, Carine M Boustany-Kari, Paolo Guarnieri, Anil Karihaloo, Daniel Traum, Hanying Yan, Kyle Coleman, Matthew Palmer, Lea Sarov-Blat, Lori Morton, Christopher A Hunter, Klaus H Kaestner, Mingyao Li, Katalin Suszták
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression. Nature genetics (2024)
Bao Khanh Trang, Alessandra Chesi, Sylvanus Toikumo, James A Pippin, Matthew C Pahl, Joan M O'Brien, Laufey T Amundadottir, Kevin K Brown, Wenli Yang, Jaclyn E Welles, Dominic Santoleri, Paul M Titchenell, Patrick Seale, Babette S Zemel, Yadav Wagley, Kurt D Hankenson, Klaus H Kaestner, Stewart A Anderson, Matthew S Kayser, Andrew D Wells, Henry R Kranzler, Rachel L Kember, Struan F A Grant
Shared and unique 3D genomic features of substance use disorders across multiple cell types. medRxiv : the preprint server for health sciences (2024)
Guoli Zhu, Deeksha Lahori, Jonathan Schug, Klaus H Kaestner
Villification of the intestinal epithelium is driven by Foxl1. bioRxiv : the preprint server for biology (2024)
Aanchal Mongia, Fatema Tuz Zohora, Noah G Burget, Yeqiao Zhou, Diane C Saunders, Yue J Wang, Marcela Brissova, Alvin C Powers, Klaus H Kaestner, Golnaz Vahedi, Ali Naji, Gregory W Schwartz, Robert B Faryabi
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. Nature communications 15 (1) (2024)
Klaus H Kaestner, Guoli Zhu, Deeksha Lahori, Jonathan Schug
Villification of the intestinal epithelium is driven by Foxl1. Research square (2024)
Abhijeet R Patil, Jonathan Schug, Ali Naji, Klaus H Kaestner, Robert B Faryabi, Golnaz Vahedi
Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program. Nature metabolism (2023)
Melissa M Rowe, Klaus H Kaestner
The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration. Cells 12 (3) (2023)
Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H Kaestner, Yehuda Tzfati
Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1. Nature communications 14 (1) (2023)
Melissa M Rowe, Klaus H Kaestner
The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration. Cells 12 (3) (2023)
Beatriz Merino, Elena Casanueva-Álvarez, Iván Quesada, Carlos M González-Casimiro, Cristina M Fernández-Díaz, Tamara Postigo-Casado, Malcolm A Leissring, Klaus H Kaestner, Germán Perdomo, Irene Cózar-Castellano
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation. Diabetologia (2023)
Melissa M Rowe, Klaus H Kaestner
The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration. Cells 12 (3) (2023)
Melissa M Rowe, Klaus H Kaestner
The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration. Cells 12 (3) (2023)
Sara Mandatori, Yawei Liu, Joana Marturia-Navarro, Mahdieh Hadi, Kristine Henriksen, Jin Zheng, Louise Munk Rasmussen, Salvatore Rizza, Klaus H Kaestner, Shohreh Issazadeh-Navikas
PRKAG2.2 is essential for FoxA1 + regulatory T cell differentiation and metabolic rewiring distinct from FoxP3 + regulatory T cells. Science advances 9 (51) (2023)
Sara Mandatori, Yawei Liu, Joana Marturia-Navarro, Mahdieh Hadi, Kristine Henriksen, Jin Zheng, Louise Munk Rasmussen, Salvatore Rizza, Klaus H Kaestner, Shohreh Issazadeh-Navikas
PRKAG2.2 is essential for FoxA1 + regulatory T cell differentiation and metabolic rewiring distinct from FoxP3 + regulatory T cells. Science advances 9 (51) (2023)
Jinping Liu, Lan Cheng, Hilana El-Mekkoussi, Charles-Antoine Assenmacher, Michelle Y Y Lee, Danielle R Jaffe, Kaisha Garvin-Darby, Ashleigh Morgan, Elisabetta Manduchi, Jonathan Schug, Klaus H Kaestner
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy. Cancer communications (London, England) (2023)
Sara Mandatori, Yawei Liu, Joana Marturia-Navarro, Mahdieh Hadi, Kristine Henriksen, Jin Zheng, Louise Munk Rasmussen, Salvatore Rizza, Klaus H Kaestner, Shohreh Issazadeh-Navikas
PRKAG2.2 is essential for FoxA1 + regulatory T cell differentiation and metabolic rewiring distinct from FoxP3 + regulatory T cells. Science advances 9 (51) (2023)
Chien-Wen Chen, Bo-Jhih Guan, Mohammed R Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A Mbow, Raul Jobava, Leena Haataja, Ajay H Zalavadia, Ashleigh E Schaffer, Hugo Lee, Thomas LaFramboise, Ilya Bederman, Peter Arvan, Clayton E Mathews, Ivan C Gerling, Klaus H Kaestner, Boaz Tirosh, Feyza Engin, Maria Hatzoglou
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity. Nature communications 13 (1) (2022)
Beatriz Merino, Elena Casanueva-Álvarez, Iván Quesada, Carlos M González-Casimiro, Cristina M Fernández-Díaz, Tamara Postigo-Casado, Malcolm A Leissring, Klaus H Kaestner, Germán Perdomo, Irene Cózar-Castellano
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation. Diabetologia 65 (8) (2022)
Oxana Dmitrieva-Posocco, Andrea C Wong, Patrick Lundgren, Aleksandra M Golos, Hélène C Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E Furth, Will Bailis, Judith R Kelsen, Kathryn E Hamilton, Klaus H Kaestner, Shelley L Berger, Jonathan A Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J Lengner, Bryson W Katona, Sergei I Grivennikov, Christoph A Thaiss, Maayan Levy
β-Hydroxybutyrate suppresses colorectal cancer. Nature 605 (7908) (2022)
Maria Fasolino, Gregory W Schwartz, Abhijeet R Patil, Aanchal Mongia, Maria L Golson, Yue J Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L May, Naomi Goldman, Wenliang Wang, Michael Feldman, Jason H Moore, Alberto S Japp, Michael R Betts, null null, Robert B Faryabi, Ali Naji, Klaus H Kaestner, Golnaz Vahedi
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes. Nature metabolism 4 (2) (2022)
Sharona Tornovsky-Babeay, Noa Weinberg-Corem, Rachel Ben-Haroush Schyr, Dana Avrahami, Judith Lavi, Eseye Feleke, Klaus H Kaestner, Yuval Dor, Benjamin Glaser
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes. Diabetologia 64 (5) (2021)
Yitzhak Reizel, Ashleigh Morgan, Long Gao, Yemin Lan, Elisabetta Manduchi, Eric L Waite, Amber W Wang, Andrew Wells, Klaus H Kaestner
Collapse of the hepatic gene regulatory network in the absence of FoxA factors. Genes & development 34 (15-16) (2020)
Mark A Atkinson, Martha L Campbell-Thompson, Irina Kusmarteva, Klaus H Kaestner
Organisation of the human pancreas in health and in diabetes. Diabetologia 63 (10) (2020)
Klaus H Kaestner, Simeon I Taylor, Ali Naji, null null, Mark A Atkinson
NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP). Diabetes 68 (7) (2019)
Ayano Kondo, Klaus H Kaestner
Emerging diverse roles of telocytes. Development (Cambridge, England) 146 (14) (2019)
Soledad A Camolotto, Shrivatsav Pattabiraman, Timothy L Mosbruger, Alex Jones, Veronika K Belova, Grace Orstad, Mitchell Streiff, Lydia Salmond, Chris Stubben, Klaus H Kaestner, Eric L Snyder
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. eLife 7 (2018)
Holly A Cyphert, Emily M Walker, Yan Hang, Sangeeta Dhawan, Rachana Haliyur, Lauren Bonatakis, Dana Avrahami, Marcela Brissova, Klaus H Kaestner, Anil Bhushan, Simeon I Taylor, Roland Stein
Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally. Diabetes 68 (2) (2018)
Samir Abu-Gazala, Elad Horwitz, Rachel Ben-Haroush Schyr, Aya Bardugo, Hadar Israeli, Ayat Hija, Jonathan Schug, Soona Shin, Yuval Dor, Klaus H Kaestner, Danny Ben-Zvi
Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes 67 (6) (2018)
Vasumathi Kameswaran, Maria L Golson, Mireia Ramos-Rodríguez, Kristy Ou, Yue J Wang, Jia Zhang, Lorenzo Pasquali, Klaus H Kaestner
The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs. Diabetes 67 (9) (2018)
Dana Avrahami, Yue J Wang, Agnes Klochendler, Yuval Dor, Benjamin Glaser, Klaus H Kaestner
β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells. Diabetes, obesity & metabolism (2018)
Kirk J Wangensteen, Yue J Wang, Zhixun Dou, Amber W Wang, Elham Mosleh-Shirazi, Max A Horlbeck, Luke A Gilbert, Jonathan S Weissman, Shelley L Berger, Klaus H Kaestner
Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology (Baltimore, Md.) 68 (2) (2018)
Maria L Golson, Klaus H Kaestner
Fox transcription factors: from development to disease. Development (Cambridge, England) 143 (24) (2017)
Rinho Kim, Karyn L Sheaffer, Inchan Choi, Kyoung-Jae Won, Klaus H Kaestner
Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation. Genes & development 30 (21) (2016)
Ellen N Elliott, Karyn L Sheaffer, Klaus H Kaestner
The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium. eLife 5 (2016)

Klaus H Kaestner.css-eqlu8i{font-size:small;padding-left:4px;} (Klaus Kaestner)

Publication Activity (10 Years)

Top Topics

Top Venues

Klaus H Kaestner (Klaus Kaestner)