High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes.
David R PowellJean-Pierre RevelliDeon D DoreeChristopher M DaCostaUrvi DesaiMelanie K ShadoanLawrence RodriguezMichael MullensQi M YangZhi-Ming DingLaura L KirkpatrickPeter VogelBrian ZambrowiczArthur T SandsKenneth A PlattGwenn H HansenRobert BrommagePublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2021)
These data support the finding of high body fat in 43 independent external published and/or IMPC KO lines. A novel obese phenotype was identified in 29 additional KO lines, with 27 still lacking the external confirmation now provided for Ksr2 and G2e3 KO mice. Undoubtedly, many mammalian obesity genes remain to be identified and characterized.
Keyphrases
- genome wide
- high fat diet induced
- weight loss
- metabolic syndrome
- type diabetes
- insulin resistance
- genome wide identification
- dna methylation
- copy number
- electronic health record
- weight gain
- bariatric surgery
- randomized controlled trial
- machine learning
- obese patients
- genome wide analysis
- artificial intelligence
- data analysis
- bioinformatics analysis