Antibiotic treatment failure in children aged 1 to 59 months with World Health Organization-defined severe pneumonia in Malawi: A CPAP IMPACT trial secondary analysis.
Tisungane MvaloAndrew G SmithMichelle EckerleMina C HosseinipourDavie KondoweR Dhananjay VaidyaYisi LiuKelly CorbettDan NansongoleTakondwa A MtimaukanenaNorman LufesiEric D McCollumPublished in: PloS one (2022)
Severe malnutrition and pre-hospital antibiotic use predicted antibiotic treatment failure in this high-risk severe pneumonia pediatric population in Malawi. Our findings suggest addressing complex sociomedical conditions like severe malnutrition and improving pneumonia etiology diagnostics will be key for better targeting interventions to improve childhood pneumonia outcomes.
Keyphrases
- early onset
- clinical trial
- healthcare
- obstructive sleep apnea
- drug induced
- respiratory failure
- randomized controlled trial
- emergency department
- physical activity
- community acquired pneumonia
- study protocol
- combination therapy
- metabolic syndrome
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- glycemic control
- data analysis
- mechanical ventilation