Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes.

Sabrina Paganoni Claire WatkinsMatthew CawsonSuzanne HendrixSamuel P DicksonNewman KnowltonJamie TimmonsMachelle ManuelMerit Cudkowicz

Published in: Muscle & nerve (2022)

Similar to the prespecified ITT analysis, post hoc analyses adjusting for treatment crossover in CENTAUR showed a significant survival benefit for PB and TURSO. Such methods may provide clinical context for observed survival outcomes in future ALS crossover trials.

Keyphrases

open label
clinical trial
double blind
randomized controlled trial
study protocol
type diabetes
heavy metals
free survival
metabolic syndrome
insulin resistance