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Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids.

Veaceslav BoldescuNatalia SucmanSidra HassanJamshed IqbalMariana NeamtuJoanna LeckaJean SévignyDenis ProdiusFliur Z Macaev
Published in: ChemMedChem (2018)
Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.
Keyphrases
  • ionic liquid
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • oxidative stress
  • clinical trial
  • study protocol
  • lymph node metastasis
  • squamous cell