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High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil.

Carlos Henrique AlencarLuciano Pamplona de Góes CavalcantiMagda Moura de AlmeidaPatrícia Pereira Lima BarbosaKellyn Kessiene de Sousa CavalcanteDéborah Nunes de MeloBruno Cavalcante Fales de Brito AlvesJorg Heukelbach
Published in: Tropical medicine and infectious disease (2021)
In Brazil, the SARS-CoV-2 vaccination program has so far prioritized people over 75 years of age. By the end of March 2021, in Ceará State, a total of 313,328 elderly people had received at least one dose of vaccine (45% Oxford-AstraZeneca/Fiocruz and 55% CoronaVac-Sinovac/Butantan), and 159,970 had received two doses (83% CoronaVac-Sinovac/Butantan and 17% Oxford-AstraZeneca/Fiocruz). After a single dose, there was already a significant reduction in COVID 19-related deaths (protection ratio: 19.31 (95% CI: 18.20-20.48), attributable protection ratio: 94.8%); higher protection ratios were observed after the application of two doses of the vaccine (132.67; 95% CI: 109.88-160.18), with an attributable protection ratio of 99.2%. SARS-CoV-2 vaccines are highly effective in reducing the number of COVID-19-related deaths in over 75-year-olds in Brazil, one of the hardest hit countries by the current pandemic.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • coronavirus disease
  • randomized controlled trial
  • systematic review
  • drug induced