Comprehensive analysis of the 21-gene recurrence score in invasive ductal breast carcinoma with or without ductal carcinoma in situ component.

Yufei Zeng Weiqi Gao Xiaosong Chen Kunwei Shen

Published in: British journal of cancer (2020)

IDC with DCIS component is associated with a lower 21-gene RS, possibly due to lower expression of proliferation and invasion genes. DCIS proportion and grade independently influenced the 21-gene RS in IDC/DCIS patients. Due to the relatively short follow-up period and low recurrence rate, the impact of the DCIS component in IDC on prognosis needs further evaluation.

Keyphrases

genome wide
genome wide identification
copy number
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
poor prognosis
dna methylation
prognostic factors
free survival
gene expression
bioinformatics analysis