Whole tumor analysis reveals early origin of the TERT promoter mutation and intercellular heterogeneity in TERT expression.

Christina L AppinChibo HongAbigail K SuwalaStephanie HilzRadhika MathurDavid A SolomonIvan V SmirnovNicholas O SteversAnny ShaiAlbert WangMitchel S BergerSusan M ChangJoanna J PhillipsJoseph F Costello

Published in: Neuro-oncology (2024)

On a tumor-wide scale, TPM is among the earliest events in glioma evolution. Intercellular heterogeneity of TERT expression, however, suggests dynamic regulation during tumor growth. TERT expression may be a tumor cell-specific biomarker.

Keyphrases

poor prognosis
single cell
binding protein
dna methylation
gene expression
mesenchymal stem cells