Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer.

Shivanshu Awasthi Anders E Berglund Julieta Abraham-MirandaRobert J RounbehlerKevin H KenslerAmparo SernaAdriana VidalSungyong YouMichael R FreemanElai DavicioniYang LiuR Jeffrey KarnesEric A KleinRobert B Den Bruce J Trock Joshua D Campbell David J EinsteinRaavi GuptaSteven P BalkPriti LalJong Y ParkJohn L ClevelandTimothy R RebbeckStephen J FreedlandKosj Yamoah

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Prostate tumors of AAM manifest a unique immune repertoire and have significant enrichment of proinflammatory immune pathways that are associated with poorer outcomes. Observed immune-oncologic differences can aid in a genomically adaptive approach to treating prostate cancer in AAM.

Keyphrases

prostate cancer
radical prostatectomy
african american
metabolic syndrome
adipose tissue
weight loss
benign prostatic hyperplasia
minimally invasive