Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.

Yiwen XiaLinjun WangZhipeng XuRuirui KongFei WangKai YinJianghao XuBowen LiZhongyuan HeLu WangHao XuDiancai ZhangLi YangJane Y WuZe-Kuan Xu

Published in: Cell proliferation (2019)

Our study reveals the inhibitory function of Slit-Robo signalling in GC and uncovers a role of USP33 in suppressing cancer cell migration and EMT by enhancing Slit2-Robo1 signalling. USP33 represents a feasible choice as a prognostic biomarker for GC.

Keyphrases

cell migration
epithelial mesenchymal transition
poor prognosis
papillary thyroid
signaling pathway
gas chromatography
squamous cell
decision making
high resolution
lymph node metastasis
liquid chromatography
tandem mass spectrometry