Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate-Resistant Prostate Cancer.
Elisabeth I HeathArchana ThakurWei ChenClara HwangChanning J PallerFrank C CackowskiJulie L BoernerLance HeilbrunMelanie P SmithDana L SchalkAmy SchienschangSarah A WhitakerAmanda PolendDaryn SmithUlka N VaishampayanBrenda DickowLawrence G LumPublished in: Cancer research communications (2024)
Our novel findings of higher expression of co-stimulatory receptor ICOS on CD4+ and CD8+ T cells in African American patients with metastatic castrate-resistant prostate cancer (mCRPC) prior and post-sipuleucel-T suggest activation of CD4+ and CD8+ T cells. The data indicate that racial differences observed in these and other immune correlates before and after sipuleucel-T warrant additional investigation to further our understanding of the immune system in African American men and other men with mCRPC.