Effectiveness of two-drug therapy versus monotherapy as initial regimen in hypertension: A propensity score-matched cohort study in the UK Clinical Practice Research Datalink.

Karine Marinier Pauline Macouillard Martine de Champvallins Nicolas Deltour Neil R Poulter Giuseppe Mancia

Published in: Pharmacoepidemiology and drug safety (2019)

Few patients initiated therapy with two drugs, reflecting UK guidelines' recommendation to start with monotherapy. This study supports the greater effectiveness of two-drug therapy as the initial regimen for BP control.

Keyphrases

clinical practice
randomized controlled trial
systematic review
ejection fraction
end stage renal disease
newly diagnosed
prognostic factors
clinical trial
emergency department
open label
stem cells
cell therapy
drug induced
adverse drug
patient reported outcomes