Associations of Sarcopenia and Body Composition Measures With Mortality After Transcatheter Aortic Valve Replacement.
Elliot J SteinColin NeillSangeeta NairJames G TerryJohn Jeffrey CarrWilliam F FearonSammy ElmariahJuyong Brian KimSamir R KapadiaDharam J KumbhaniLinda D GillamBrian K WhisenantNishath QuaderAlan ZajariasFrederick G P WeltAnthony A BavryMegan CoylewrightRobert N PianaRavinder R MallugariAnna VatterottNatalie JacksonShi HuangBrian R LindmanPublished in: Circulation. Cardiovascular interventions (2024)
Among patients with symptomatic severe aortic stenosis and comprehensive sarcopenia and body composition phenotyping, gait speed was the only sarcopenia measure associated with post-TAVR mortality. Lower visceral fat was also associated with increased risk pointing to an obesity paradox also observed in other patient populations. These findings reinforce the clinical utility of gait speed as a measure of risk and a potential target for adjunctive interventions alongside TAVR to optimize clinical outcomes.
Keyphrases
- body composition
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve
- skeletal muscle
- aortic valve replacement
- insulin resistance
- transcatheter aortic valve implantation
- resistance training
- bone mineral density
- ejection fraction
- community dwelling
- left ventricular
- adipose tissue
- metabolic syndrome
- type diabetes
- cerebral palsy
- weight loss
- cardiovascular events
- physical activity
- coronary artery disease
- weight gain
- early onset
- case report
- high throughput
- high fat diet induced
- fatty acid
- single cell
- genetic diversity