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Corticosteroid plus glycyrrhizin therapy for chronic drug- or herb-induced liver injury achieves biochemical and histological improvements: a randomised open-label trial.

Jia-Bo WangAng HuangYijin WangDong JiQing-Sheng LiangJun ZhaoGuangde ZhouShuhong LiuMing NiuYing SunHui TianGuang-Ju TengBin-Xia ChangJing-Feng BiXiao-Xia PengShaojie XinHuan XieXiong MaYi-Min MaoSuthat LiangpunsakulRomil SaxenaGuruprasad P AithalXiao-He XiaoJing-Min ZhaoZheng-Sheng Zou
Published in: Alimentary pharmacology & therapeutics (2022)
This study provides the first clinical evidence that corticosteroid plus glycyrrhizin therapy for chronic DILI with or without AIH-like features can achieve both biochemical response and histological improvements with good safety. (ClinicalTrials.gov, NCT02651350).
Keyphrases
  • open label
  • clinical trial
  • phase iii
  • phase ii
  • study protocol
  • drug induced
  • double blind
  • randomized controlled trial
  • emergency department
  • placebo controlled
  • squamous cell carcinoma
  • radiation therapy
  • adverse drug