Synergistic Effects of Kartogenin and Transforming Growth Factor-β3 on Chondrogenesis of Human Umbilical Cord Mesenchymal Stem Cells In Vitro.

Yanhong ZhaoBinhong TengXun SunYunsheng DongShufang WangYongcheng HuZheng WangXinlong MaQiang Yang

Published in: Orthopaedic surgery (2020)

The combination of KGN and TGF-β3 had synergistic effects and induced hUCMSC chondrogenesis. This could represent a new approach for clinical application and studies on cartilage repair and regeneration.

Keyphrases

transforming growth factor
umbilical cord
mesenchymal stem cells
epithelial mesenchymal transition
endothelial cells
high glucose
stem cells
cancer therapy
bone marrow
cell therapy
diabetic rats
induced pluripotent stem cells
pluripotent stem cells
extracellular matrix
case control
stress induced