Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke.
Yong WangZhuohang LiuLuyu LiZengyu ZhangKai ZhangMin ChuYang LiuXueyu MaoDi WuDongsheng XuJing ZhaoPublished in: Journal of nanobiotechnology (2024)
Collectively, we illustrated a novel potential therapeutic mechanism that Fxr2 in ADSC-Exo could alleviate the M2 microglia ferroptosis via regulating Atf3/Slc7all expression, hence inhibiting the inflammatory microenvironment, improving neurofunction recovery in cerebral I/R injury. We obtained a novel exosome, M2pep-ADSC-Exo, through engineered modification, which exhibits improved targeting capabilities toward M2 microglia. This provides a new avenue for the treatment of stroke.
Keyphrases
- inflammatory response
- neuropathic pain
- cell death
- atrial fibrillation
- stem cells
- cancer therapy
- poor prognosis
- cerebral ischemia
- mesenchymal stem cells
- subarachnoid hemorrhage
- oxidative stress
- spinal cord
- endoplasmic reticulum stress
- transcription factor
- brain injury
- binding protein
- drug delivery
- blood brain barrier
- cerebral blood flow