SBR-Blood: systems biology repository for hematopoietic cells.
Jens LichtenbergElisabeth F HeustonTejaswini MishraCheryl A KellerRoss C HardisonDavid M BodinePublished in: Nucleic acids research (2015)
Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles.
Keyphrases
- induced apoptosis
- dna methylation
- cell cycle arrest
- single cell
- endoplasmic reticulum stress
- gene expression
- poor prognosis
- health information
- emergency department
- endothelial cells
- cell therapy
- cell proliferation
- signaling pathway
- binding protein
- stem cells
- machine learning
- electronic health record
- high throughput
- mass spectrometry