Dynamics in the expression of programmed death ligand 1 and cluster of differentiation 163 in the tumor microenvironment of uterine cervical cancer: a single-center retrospective study.

Yusaku Miyata Etsuyo Ogo Toshi Abe Hideki Hirata Naotake Tsuda Kimio Ushijma Akihiko Kawahara Jun Akiba Hitoshi Obara Tatsuyuki Kakuma

Published in: Radiation oncology (London, England) (2023)

The expression rates of CD163 and PD-L1 in the TME during brachytherapy were related to treatment response and the 2-year PFS. This study may increase our understanding of tumor-associated immunity in the TME and aid in the development of therapies targeting PD-L1 or M2 macrophages in the TME in conjunction with RT, especially brachytherapy, for cervical cancer patients.

Keyphrases

poor prognosis
high dose
radiation therapy
binding protein
locally advanced
low dose
cancer therapy
drug delivery