Patient specific, imaging-informed modeling of rhenium-186 nanoliposome delivery via convection-enhanced delivery in glioblastoma multiforme.
Ryan T WoodallDavid A HormuthChengyue WuMichael R A AbdelmalikWilliam T PhillipsAnde BaoThomas J R HughesAndrew J BrennerThomas E YankeelovPublished in: Biomedical physics & engineering express (2021)
Convection-enhanced delivery of rhenium-186 (186Re)-nanoliposomes is a promising approach to provide precise delivery of large localized doses of radiation for patients with recurrent glioblastoma multiforme. Current approaches for treatment planning utilizing convection-enhanced delivery are designed for small molecule drugs and not for larger particles such as186Re-nanoliposomes. To enable the treatment planning for186Re-nanoliposomes delivery, we have developed a computational fluid dynamics approach to predict the distribution of nanoliposomes for individual patients. In this work, we construct, calibrate, and validate a family of computational fluid dynamics models to predict the spatio-temporal distribution of186Re-nanoliposomes within the brain, utilizing patient-specific pre-operative magnetic resonance imaging (MRI) to assign material properties for an advection-diffusion transport model. The model family is calibrated to single photon emission computed tomography (SPECT) images acquired during and after the infusion of186Re-nanoliposomes for five patients enrolled in a Phase I/II trial (NCT Number NCT01906385), and is validated using a leave-one-out bootstrapping methodology for predicting the final distribution of the particles. After calibration, our models are capable of predicting the mid-delivery and final spatial distribution of186Re-nanoliposomes with a Dice value of 0.69 ± 0.18 and a concordance correlation coefficient of 0.88 ± 0.12 (mean ± 95% confidence interval), using only the patient-specific, pre-operative MRI data, and calibrated model parameters from prior patients. These results demonstrate a proof-of-concept for a patient-specific modeling framework, which predicts the spatial distribution of nanoparticles. Further development of this approach could enable optimizing catheter placement for future studies employing convection-enhanced delivery.
Keyphrases
- magnetic resonance imaging
- end stage renal disease
- computed tomography
- ejection fraction
- small molecule
- chronic kidney disease
- contrast enhanced
- peritoneal dialysis
- prognostic factors
- clinical trial
- randomized controlled trial
- high resolution
- positron emission tomography
- low dose
- radiation therapy
- deep learning
- big data
- patient reported outcomes
- mass spectrometry
- ultrasound guided
- optical coherence tomography
- subarachnoid hemorrhage
- low cost
- current status
- resting state
- functional connectivity